To determine whether the inhibition of p MAPK in activated

2018-10-20

To determine whether the inhibition of p38 MAPK in activated huSCs could maintain their proliferative potential and prevent expression of genes for myogenic differentiation, we grew the GDC-0994 in the presence of a small molecule p38 inhibitor (p38i; SB 203580) and analyzed both their transcriptio

Our gene chip analysis also revealed

2018-10-20

Our gene chip analysis also revealed a robust upregulation of metallothionein (MT) family members that are involved in metal metabolism and detoxification, as well as reactive oxygen species (ROS) scavenging. Overexpression of MT has been shown to protect mice from streptozotocin (STZ)-induced β cel

Introduction The pluripotency promoting role of the reprogra

2018-10-20

Introduction The pluripotency-promoting role of the reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) is widely appreciated. However, these reprogramming factors also promote expression of non-pluripotency genes. For example, OCT4 (Pou5f1) directly promotes expression of genes important for mo

br Results br Discussion The

2018-10-20

Results Discussion The range of cell types in Haemopedia makes identification of lineage-specific genes more rigorous. The genes that we have identified as lineage signatures are highly specific to each lineage and are lineage specific in other datasets (Figure S5). This provides a powerful re

Previous studies reported that the introduction

2018-10-20

Previous studies reported that the introduction of KitW41 or KitWv mutations into BALB-RG or NSG mice could render mouse HSCs uncompetitive to donor human HSCs (Cosgun et al., 2014; McIntosh et al., 2015). They also showed that human HSPCs injected at a high dose (5 × 104 to 3 × 105 CD34+ CB cells),

Hello world!

2018-07-29