Introduction The pluripotency promoting role of the reprogra

2018-10-20

Introduction The pluripotency-promoting role of the reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) is widely appreciated. However, these reprogramming factors also promote expression of non-pluripotency genes. For example, OCT4 (Pou5f1) directly promotes expression of genes important for mo

br Results br Discussion The

2018-10-20

Results Discussion The range of cell types in Haemopedia makes identification of lineage-specific genes more rigorous. The genes that we have identified as lineage signatures are highly specific to each lineage and are lineage specific in other datasets (Figure S5). This provides a powerful re

Previous studies reported that the introduction

2018-10-20

Previous studies reported that the introduction of KitW41 or KitWv mutations into BALB-RG or NSG mice could render mouse HSCs uncompetitive to donor human HSCs (Cosgun et al., 2014; McIntosh et al., 2015). They also showed that human HSPCs injected at a high dose (5 × 104 to 3 × 105 CD34+ CB cells),

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2018-07-29