• It has long been known that mesenchymal

  2018-10-24

  

  It has long been known that mesenchymal stem buy Bafilomycin A1 (MSCs) are capable of differentiation along the mesenchymal lineages, forming adipose tissue (adipocytes), cartilage (chondrocytes) and bone (osteoblasts) (Pittenger et al., 1999, 2000). MSCs can be isolated from a number of tissues, in

• Recently human umbilical cord hUC

  2018-10-24

  

  Recently, human umbilical cord (hUC) has been investigated as a source of purchase SAR405 with stem/progenitor cell properties. hUC is a desirable source of stem/progenitor cells as it is routinely discarded after delivery, collection is non-invasive and an abundant number of cells are present in co

• We have found a rare population of pNSCs

  2018-10-24

  

  We have found a rare population of pNSCs in the adult mammalian brain (termed AdpNSCs). We isolated cells from the adult periventricular region that generate clonally derived, self-renewing, and multipotent colonies in vitro in the presence of LIF. These LIF colonies can be passaged to give rise to

• It has been reported that BM MSCs derived from frozen

  2018-10-24

  

  It has been reported that BM-MSCs derived from frozen MNCs have less immunosuppressive effects than those derived from fresh MNCs (Samuelsson et al., 2009). We derived different BM-MSC lines from both frozen MNCs and fresh (never frozen) whole BM. Both types had similarly negligible effects in the E

• br Experimental Procedures br Author

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Adult vertebrate muscle has an exceptional capacity for regeneration, mediated by a dedicated population of muscle stem cells. These muscle stem cells, termed satellite cells, were first identified by their unique

• Main Text br Acknowledgments The authors would

  2018-10-24

  

  Main Text Acknowledgments The authors would like to thank all delegates for their input into the workshops that led to the contents of this white paper (Table S2). Introduction The type II clustered regularly interspaced short palindromic repeat (CRISPR) systems and the associated Cas9 nucle

• br Results br Discussion Here we demonstrate

  2018-10-24

  

  Results Discussion Here, we demonstrate the generation of hESC reporter lines without the use of drug selection for both active and silent genes through the use of the iCRISPR system. Selection-free gene targeting eliminates the need for removal of drug-resistance cassette after identification

• We and others have shown previously that the evolutionarily

  2018-10-24

  

  We and others have shown previously that the evolutionarily conserved Notch signaling pathway plays an important role in early embryonic pituitary development (Kita et al., 2007; Raetzman et al., 2004, 2007; Zhu et al., 2006). Delta/Notch signaling, mediated by the critical transcription factor RBP-

• dna staining br Results br Discussion The

  2018-10-24

  

  Results Discussion The Wnt signaling pathway has emerged as the dominant self-renewal pathway for various adult-type stem cells and is required for maintenance of embryonic as well as induced pluripotent stem cells. In the hematopoietic system, only mild increased Wnt dosages result in higher

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We are grateful for the technical assistance of Maria Ensthaler and the support by the “Core facility Cell Sorting.” We also thank the Research Core Unit Transcriptomics of Hannover Medical School for generating and processing the

• The aim of the present study

  2018-10-24

  

  The aim of the present study was to explore the induction of apoptosis in tumors formed from hiPSC-derived products. Our results demonstrate that apoptosis can be induced by CID in tumors grown from transplanted gap 26 that have undergone differentiation after engraftment and have been in close int

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank A. Villanueva, C. Saura, C. Cruz, A. Fernández, E. Nadal, M. Martin, and R. Iggo for reagents and helpful advice, A. Welm and Y. DeRose for sharing PDX models, V. Peg, X. Serres, J. Balmaña, J. Pérez, and C. Hierro for pr

• br Results br Discussion Control of cell cycle

  2018-10-24

  

  Results Discussion Control of cell-cycle progression has been linked to the regulation of self-renewal and cell-fate determination in ESCs (Pauklin and Vallier, 2013; Singh et al., 2015; White and Dalton, 2005). It has been reported that the length of the G1 phase defines the capacity of multi

• pp1 While relevant the two original dimensions of

  2018-10-24

  

  While relevant, the two original dimensions of patient-centeredness did not completely capture the range of PPC types participants discussed. Both qualitative and quantitative data supported the importance of the third dimension: guiding patient behaviors (“showing the path”). Participants were high

• Our original contribution to the literature is

  2018-10-24

  

  Our original contribution to the literature is threefold. First, the study uses the 12-item GHQ-12 as separate items instead of considering them as a summary score. To our knowledge, it is the first time that this has been attempted within the field of social capital. Employing as dependent variable

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