• A-366 The implications of the sieve analyses along

  2018-11-13

  

  The implications of the sieve analyses along with immunologic and viral data suggest that both positions 169 (V2) and 307 (V3) are subject to immune pressure by RV144-induced Abs that target 169 (Liao et al., 2013; Zolla-Pazner et al., 2013) and 307 (XP Kong, personal communication and Montefiori et

• The immunologic data demonstrate the

  2018-11-13

  

  The immunologic data demonstrate the broad cross-reactivity of vaccine-induced V3 Abs (Fig. 1 and Table 2) and recapitulate studies documenting the ability of many V3 mAbs to cross-react immunologically with diverse V3 peptides (Gorny et al., 1997), to capture virions from multiple subtypes (Nyambi

• br Material and Methods br

  2018-11-13

  

  Material and Methods Results Discussion We document the expression of EBV viral miRNAs by three independent methods, small RNA sequencing, qRT-PCR and miRNA-ISH in malignant B cells, plasma and bone marrow biopsies of patients with CLL. It is noteworthy that more than 90% of adults older th

• Aside from induction of cold shock proteins however little i

  2018-11-13

  

  Aside from induction of cold-shock proteins however, little is known of other fundamental cellular stress pathways in relation to cooling and their potential relevance to hypothermic preconditioning (Hofman et al., 2012; van der Harg et al., 2014). Hypothermia can induce protein unfolding and disrup

• Five year survival proportions for melanoma are poor

  2018-11-13

  

  Five-year survival proportions for melanoma are poor for patients with metastatic disease, however if disease is detected in its early stages, then survival is one of the highest for all cancers. Even for those with metastases, survival differs depending on the extent of disease spread. Patients wit

• herpes simplex virus infection br Methods br Results Between

  2018-11-13

  

  Methods Results Between August and November 2011, one hundred eighteen (118) males were recruited from the herpes simplex virus infection (Fig. 1). The baseline characteristics are presented in Table 1. From all participants, who received placebo or trastuzumab (Fig. 1), 261 routine chemistr

• br Funding and Role of Funder br Conflicts of Interest

  2018-11-13

  

  Funding and Role of Funder Conflicts of Interest Author Contributions Acknowledgements This work was supported by the Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. We thank Dr. Oksana Gavrilova for her excell

• Subjects occupying the left side of the

  2018-11-13

  

  Subjects occupying the left side of the redesigned decision tree had a low PERSEVERE-based mortality risk. In these subjects, if IL8 decreased by at least 300ng/ml from day 1 to day 3, the probability of a complicated course was 6.3% in the context of a day 1 IL8 concentration ≤525ng/ml (terminal no

• We previously characterized a new type of stem cell

  2018-11-13

  

  We previously characterized a new type of stem cell from human cord blood, designated a cord blood-derived multipotent stem cell (CB-SCs) (Zhao et al., 2006; Zhao and Mazzone, 2010). CB-SCs display a unique phenotype with both embryonic and hematopoietic markers that distinguish them from other know

• The clinical utility of RILA is high as mentioned

  2018-11-13

  

  The clinical utility of RILA is high as mentioned in the STROGAR guidelines (Kerns et al., 2014). For example, patients identified as low risk of late effects might be offered a higher dose with modern techniques or radiotherapy in combination with systemic therapies with the aim of improving local

• Classic KS predominantly affects elderly people over years m

  2018-11-12

  

  Classic KS predominantly affects elderly people over 50 years, many of whom do not tolerate aggressive chemotherapy regimens well due to frequent comorbidity and diminished cardiovascular and bone marrow reserves. Classic KS follows an indolent course (average survival is 10–15 years) requiring long

• A possible way to suppress

  2018-11-12

  

  A possible way to suppress the formation and growth of macroscopic cracks is to prestress the ceramic material. The influence of prestress and the related failure modes of impacted ceramics have been studied by several authors. The papers [18–20] report experimental data on small calibre projectiles

• back off br CIB implementation case study The case study is

  2018-11-12

  

  CIB implementation (case study) The case study is an application of the proposed methodology on two well-known SaaS providers, namely, Microsoft (MS) Dynamics CRM 2015 and SugarCRM. However, this methodology can be used for other SaaS providers, e.g., SAP ERP, and Oracle E-Business suites ERP app

• vesicular monoamine transporter Third analysis of variance A

  2018-11-12

  

  Third, analysis of variance (ANOVA) test as well as Kruskal–Wallis test was conducted to determine if there is a significant amount of variation among the industrial sectors. According to the results that are reported in Table 2, The F-statistic as well as the χ2-statistic is significant in all case

• br The role of p SQSTM in selective autophagy The

  2018-11-12

  

  The role of p62/SQSTM1 in selective autophagy The most primitive and essential function of autophagy is to selectively degrade cytoplasmic components in the case of starvation and produce human leukocyte elastase and ATP to maintain the energy metabolism cycle of the body. With the deepening of t

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