• Two other groups subsequently published further data on iPSC

  2019-05-17

  

  Two other groups subsequently published further data on iPSCs models of ARVC that have improved our understanding of this disease. Kim et al. developed iPSC models using episomal methods from 2 ARVC patients, as well as with PKP2 mutations . Detailed electrophysiological characterization of mutant a

• br Mega cohort studies Remote

  2019-05-17

  

  Mega-cohort studies Remote monitoring collects a wealth of data from large numbers of patients which are not subject to saturation or overwritten memory counters within any implantable device. These databases provide an opportunity to better understand system function, patient condition, and dise

• Catheter ablation of a concealed right anteroseptal AV

  2019-05-17

  

  Catheter ablation of a concealed right anteroseptal AV bypass tract was successfully performed in our patient. Catheter ablation of the anteroseptal accessory pathway did not affect normal AV conduction. The effective refractory period of the fast AV node was 380ms at a pacing Anti-cancer Compound L

• The nutrition support team NST estimated his

  2019-05-17

  

  The nutrition support team (NST) estimated his nutritional status and began the intervention. An inadequate calorie intake (due to swallowing difficulty) induced malnutrition in the patient; his bodyweight (BW) loss exceeded 8% in 3 months, his body mass index (BMI) was 21 kg/m2, triceps skinfold th

• A year old woman presented to our clinic with

  2019-05-17

  

  A 54-year-old woman presented to our clinic with palpitation and shortness of breath. Six years previously, she underwent successful catheter ablation for focal atrial tachycardia (AT) originating from the SB202190 of the right atrial appendage and right side of the fossa ovalis. However, AT origin

• Repurposing use of approved drugs for new

  2019-05-17

  

  Repurposing (use of approved drugs for new indications) or repositioning (use of drugs whose development was not continued for new indications) of existing drugs has been put forward as a method to overcome some of these issues. Indeed, drug repositioning and repurposing could lead to higher rates o

• Paraguay es puntual en la redacci

  2019-05-17

  

  Paraguay es puntual en la redacción del Artículo 8 de su Constitución Nacional cuando dice que “Las actividades susceptibles de producir alteración ambiental serán reguladas por la ley. Asimismo, ésta podrá restringir o prohibir aquéllas que califique peligrosas”. Describe allí las actividades que p

• br Transici n y representaci

  2019-05-16

  

  Transición y representación ¿Qué pasó con esa idea del campesino nacional, anacrónico y en conflicto con la modernidad en el momento posrevolucionario? Su reinscripción como una idealización coincide con los pactos de transición de régimen. A la vez, la participación militar de los campesinos com

• Lelijveld and colleagues suggest that some catch

  2019-05-16

  

  Lelijveld and colleagues suggest that some catch-up growth occurs after discharge, even outside the expected 1000-day window, in the absence of any specific intervention. The real question now is to establish how this spontaneous partial recovery after treatment for SAM can be improved. During treat

• A structured inherited arrhythmia or heart disease

  2019-05-16

  

  A structured inherited arrhythmia (or heart disease) clinic provides the platform for optimized multidisciplinary evaluation and management of patients and families with suspected inherited heart disease. The collective efforts of the core staff and access to a variety of experts in related discipli

• Although a well experienced group reported a very high

  2019-05-16

  

  Although a well experienced group reported a very high success rate of 80% after catheter ablation even in patients with congestive heart failure [40], the evidence described above suggests that catheter ablation alone is not sufficient to treat AF in patients with hemodynamic deterioration. This in

• In order to treat metastatic

  2019-05-16

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• Preclinical studies have shown that adipocytes and MSCs

  2019-05-16

  

  Preclinical studies have shown that adipocytes and MSCs play an important role in migration and dissemination of cancer ci-1033 [55,56]. Concerning osteosarcoma, one publication has reported that human MSCs injected through the caudal vein of mice bearing Saos-2- induced an increase in tumor volume

• Funding secured by Not applicable Data collection Sheldon M

  2019-05-16

  

  Funding secured by: Not applicable. Data collection: Sheldon M. Singh, MD, Ramanan Kumareswaran, MD. Conflict of interest Acknowledgments Introduction Early repolarization pattern (ERP) is characterized by an elevation greater than 0.1mV of the junction between the end of the QRS complex

• br Discussion We describe an additional

  2019-05-15

  

  Discussion We describe an additional diagnosis to consider when BVT is identified. One of the proposed mechanisms of BVT include elevated intracellular calcium, causing delay after depolarization in anatomically separate parts of the conducting system. Baher et al. [1] proposed that two separate

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