• In our recent study we established

  2019-08-20

  

  In our recent study, we established a procedure to examine the chromatin binding of XRCC4 using a biochemical fractionation analysis using a detergent Nonidet P-40 [22]. In this study, we investigated the role of LIG4 and its subdomains in the recruitment of XRCC4/LIG4 complex to chromatin. Mater

• Diacylglycerol kinase was one of the hits identified from th

  2019-08-20

  

  Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a 93 6 of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61], [62], [63]. Some of the

• br Deregulation of CDK Many neurotoxic

  2019-08-20

  

  Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic gamma-Glu-Cys damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is activa

• Alpha SYN has no direct effect on forskolin induced CREB

  2019-08-19

  

  Alpha-SYN has no direct effect on forskolin-induced CREB phosphorylation, but rather blocks the stimulation of CRE-mediated transcription in the nucleus. Previously we suggested that α-SYN can enter the nucleus and is present in both cytosolic and nuclear fractions without direct interaction between

• BAMB-4 AAG has a broad substrate specificity and besides met

  2019-08-19

  

  AAG has a broad substrate specificity and besides 3-methyladenine can excise other altered purine residues, such as the minor lesions hypoxanthine and 1, N6-ethenoadenine from DNA. AAG initially activates these neutral base lesions by protonation of the base to allow for general BAMB-4 catalysis [1

• Till date several predictive models

  2019-08-19

  

  Till date, several predictive models have been developed by different research groups to speed up the process of library selection and drug optimization (Walters et al., 1999, Caldwell, 2000, Plewczynski et al., 2006, Wang and Ramnarayan, 1999, Pogorelcnik et al., 2015, Greenbaum et al., 2002, Sadow

• br Other Alterations in Triglyceride Metabolism in DGAT Defi

  2019-08-19

  

  Other Alterations in Triglyceride Metabolism in DGAT-Deficient Mice Consistent with the enzyme\'s ubiquitous expression pattern, DGAT deficiency also altered triglyceride metabolism in other tissues. For example, postpartum Dgat−/− female mice were unable to nurse their young owing to an absence

• We examined the function of immobilised THPs by

  2019-08-19

  

  We examined the function of immobilised THPs by seeding cells transfected with DDR2-Flag on derivatised crosslinked collagen films, then detecting the phosphorylation of tyrosine 740 (Y740) on the intracellular domain of DDR2 [50]. This regulatory residue is a target for the intracellular tyrosine k

• In the pleural exudates which reflect

  2019-08-17

  

  In the pleural exudates, which reflect the in vivo conditions, the concentrations of CysLTs and PGE2 were quite similar. However, when cancer follow-up were cultured for 24 h, both analyses of cell culture medium and cell incubations with Ca2+ ionophore showed low levels of CysLTs. In contrast, the

• br Experimental Procedures br Acknowledgments br Introductio

  2019-08-17

  

  Experimental Procedures Acknowledgments Introduction The ability of the affiliative and nurture hormone oxytocin (OT) to attenuate stress has been observed across psychological, neurological, and physiological levels [1], [2]. We and others have demonstrated that, in the gut, OT can lessen

• Itch also known as astrophin interacting protein AIP is

  2019-08-17

  

  Itch, also known as astrophin-1 interacting protein-4 (AIP4), is a HECT domain-E3 ligase. It was discovered in 1998 in mouse coat color genetic studies which displayed the disruption caused by the Itch gene inducing a lethal autoimmune inflammatory condition. The substrates of Itch are transmembrane

• In general cellular senescence is

  2019-08-17

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• Although PQQ has nutritional importance and pharmacological

  2019-08-17

  

  Although PQQ has nutritional importance and pharmacological effects in higher organisms, including humans [15], until recently, there was no clear evidence for the use of PQQ as a co-factor in a eukaryotic enzyme. This review presents a novel eukaryotic PQQ-dependent quinohemoprotein recently discov

• Several in vivo human studies

  2019-08-17

  

  Several in vivo human studies have produced conflicting results for evaluating the inhibition of OCs on the metabolism of CYP3A substrates. Balogh et al. [12] demonstrated an approximately 25% inhibition of CYP3A activities in vivo after the administration of an OC containing 30μg of ethinylestradio

• CDK lacks DNA binding domains and nuclear localization seque

  2019-08-17

  

  CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX

15629 records 956/1042 page Previous Next First page 上5页 956957958959960 下5页 Last page