• A surprising second functional effect was found in culture

  2020-07-29

  

  A surprising second functional effect was found in culture experiments. Inclusion of LTD4 reduced the frequency of Fas receptor (CD95) expression. Once again, this effect, although modest, was reversed by a cysLT1 receptor antagonist. The biologic significance of this effect or its mechanism remaine

• Taken together this study gives first insights into the comp

  2020-07-29

  

  Taken together, this study gives first insights into the complex effect of DNMT inhibition on pattern separation. Acute administration of RG108 enhanced pattern separation performance measured with the OPS task and increased Bdnf1 expression. However, this effect was only acute, and was not present

• The chemokine receptor CXCR plays a

  2020-07-28

  

  The chemokine receptor CXCR5 plays a significant role in CLL/SLL pathogenesis. The receptor protein has been identified on greater than 90% of patient samples [3], [4], [10], [72] and shown not to be affected by IGHV mutation status [90]. Depending on the study, CXCR5 protein was either similarly ex

• p is activated in response to several malignancy associated

  2020-07-28

  

  p53 is activated in response to several malignancy-associated stress signals, giving rise to the inhibition of tumor cell growth (Garritano et al., 2013). Several responses can be elicited by p53, including Brefeldin A arrest, senescence, differentiation and apoptosis. The p53 protein is controlled

• Adenosine is a naturally occurring

  2020-07-28

  

  Adenosine is a naturally occurring purine nucleoside that is distributed ubiquitously throughout the body as a metabolic intermediary. In the brain, adenosine functions as an important upstream neuromodulator of a broad spectrum of neurotransmitters, receptors and signaling pathways. By acting throu

• Funding sources This study was funded by

  2020-07-28

  

  Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg

• br Materials and methods br Results br

  2020-07-28

  

  Materials and methods Results Discussion The serine/threonine kinase DAPK plays an important role in a wide range of different cell death modes (Lin et al., 2010). To date, only a limited number of proteins that interact with DAPK have been identified. Recently, we have described a novel in

• CRF dependent sensitization of VTA

  2020-07-28

  

  CRF-dependent sensitization of VTA glutamate release after repeated administration of cocaine has also been documented in an electrophysiological study recording from glutamatergic synapses in VTA containing slices from mice repeatedly treated with cocaine [44]. In this case, both pre and postsynapt

• The importance of mitochondria as site

  2020-07-28

  

  The importance of mitochondria as site of aerobic oxidation of metabolic fuels, such as FA, has been recognized for a long time. It has been observed that the number of mitochondria may vary in response to cellular metabolic requirements and hormonal environment (Gao et al., 2014). In order to susta

• br Discussion The CPH model the Bayesian network learning fr

  2020-07-28

  

  Discussion The CPH model, the Bayesian network learning from data, and the K–M estimates have a similar predictive ability when there are enough data to learn from. However, when there are few data records, the survival curves derived from the K–M estimate and Bayesian network learning from data

• In this study we examined the role of a

  2020-07-28

  

  In this study we examined the role of a well characterized genetic polymorphism in the COMT gene in mediating cognitive antipsychotic treatment effects in first episode psychosis (FEP). We considered catechol-O-methyltransferase (COMT) to be a potentially important baseline consideration in a pharma

• Using the amino acid sequence encoded by the TH

  2020-07-28

  

  Using the amino AG-221 mg sequence encoded by the TH1 proline-3-hydroxylase gene, a series of synthetic oligonucleotides were designed and synthesized by us. These oligonucleotides were then assembled and PCR amplified to form a single double-stranded DNA fragment that contained the coding sequence

• Cholesterol concentration in plasma depends on

  2020-07-28

  

  Cholesterol concentration in plasma depends on the amount of cholesterol from the diet and its intestinal absorption, on de novo synthesis, and on its biliary excretion [10]. Previous studies have reported increased intestinal cholesterol Z-FA-FMK in non-FH ADH subjects that may partially explain p

• Estrogens also exert their effects by binding to the G

  2020-07-27

  

  Estrogens also exert their effects by binding to the G protein-coupled estrogen receptor 1 (GPER-1) also known as G protein-coupled receptor 30 (GPR30) [[11], [12], [13]]. Several reports have suggested that estrogen, through the activation of GPER-1, can also mediate cellular functions including gr

• Interestingly we found reduced expression of pIgR in NPs Fig

  2020-07-27

  

  Interestingly, we found reduced expression of pIgR in NPs (Fig 3), despite the fact that pIgR expression can be induced by local immunoglobulin production. Because pIgR is known to be expressed in glandular epithelium, its reduced expression in NPs might be due to the recently documented reduction

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