• br Conclusion In conclusion our findings

  2020-12-24

  

  Conclusion In conclusion, our findings do not suggest that HT is an important determinant of future AD risk and are in line with a recent Cochrane review stating that HT is not indicated for preventing dementia or cognitive decline in postmenopausal women [13]. Contributors Conflict of inte

• We not only found that the ISR leads to

  2020-12-24

  

  We not only found that the ISR leads to attenuation of conventional cap-dependent translation with no change in RAN translation of the G4C2 expanded repeat, but also that GA translation from the expanded repeat (but not from 5 G4C2 repeats, perhaps because the protein product does not aggregate) is

• Recently a method for in

  2020-12-24

  

  Recently, a method for in vivo photoactivation of Sephin 1 receptor expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported th

• br Experimental Procedures br Acknowledgments We thank R Bri

  2020-12-24

  

  Experimental Procedures Acknowledgments We thank R. Brink for providing HEL2x, M. Tanaka for CD169DTR mice, R. Lathe for making Cyp7b1+/− mice available, and M. Barnes and A. Reboldi for comments on the manuscript. T.Y. is an Irvington Institute Postdoctoral Fellow at the Cancer Research Insti

• br Materials and methods br Results br Discussion br Conflic

  2020-12-23

  

  Materials and methods Results Discussion Conflict of interest Introduction Dopamine-β-hydroxylase (DβH) deficiency is a rare autosomal recessive disorder characterized by the congenital absence of DβH, the enzyme converting dopamine to noradrenaline in sympathetic nerve terminals and

• Concerning family A GPCRs although

  2020-12-23

  

  Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e

• If the factors needed for A NHEJ are

  2020-12-23

  

  If the factors needed for A-NHEJ are not completely defined and the A-NHEJ reaction mechanism nebulous, it is also fair to say that the biological role(s) of A-NHEJ is even more poorly understood. Most of the current interest in A-NHEJ, however, stems from its implicated use in the chromosomal trans

• If the factors needed for A NHEJ are

  2020-12-23

  

  If the factors needed for A-NHEJ are not completely defined and the A-NHEJ reaction mechanism nebulous, it is also fair to say that the biological role(s) of A-NHEJ is even more poorly understood. Most of the current interest in A-NHEJ, however, stems from its implicated use in the chromosomal trans

• DGAT is specifically responsible for endogenous

  2020-12-23

  

  DGAT2 is specifically responsible for endogenous synthesis of TAGs which are then packed into cytosolic LDs in the cytosol for storage and luminal apolipoprotein B (apoB)-containing LDs in the ER lumen destined for VLDL secretion [122,127]. DGAT2 can also synthesize TAG using exogenous FAs and suppo

• br Enzymes involved in microbial steroid degradation are

  2020-12-23

  

  Enzymes involved in microbial steroid degradation are generally not expressed constitutively, but they are upregulated depending on which steroid substrates are present [17,81]. Thus, a cell-free extract prepared from testosterone-adapted C. testosteroni ATCC 11996 cells displayed a 1(2)-dehydroge

• Expression of DDR in endothelial cells has

  2020-12-23

  

  Expression of DDR1 in endothelial cells has been previously described in human corneal blood vessels, and more recently, in murine atherosclerotic plaques (Franco et al., 2008, Mohan et al., 2001). So far, there is a lack of evidence for DDR1 expression in endothelial cells in the mouse sigma recept

• Autophagy alterations are frequently reported as one of the

  2020-12-23

  

  Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein 92 8 in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were described as a main ge

• Atropine synthesis ARA metabolites which are produced throug

  2020-12-23

  

  ARA metabolites, which are produced through cytochrome P450 (CYP450) enzymes influence cardiovascular homeostasis. Human CYP4A11 and CYP1A2 metabolize ARA to 20-hydroxyecostearonic Atropine synthesis (20-HETE) [11], which is a vasoconstrictor [12], platelet activator [13] and naturetic in the kidney

• Introduction Cyclin dependent kinases CDKs are a family of

  2020-12-23

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as dofetilide and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-l

• Although the phase I clinical trial of LMB was

  2020-12-23

  

  Although the phase I clinical trial of LMB was unsuccessful, the detailed review of this trial only mentions some malaise and anorexia as side effects, which are common for most effective chemotherapeutic drugs. These side effects may diminish if lower doses are administered. In view of the novel CR

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