• br Materials and methods br

  2021-03-22

  

  Materials and methods Results Discussion The incretin hormones potently stimulate insulin secretion, and it is generally assumed that this is mediated by an endocrine mechanism such that GIP and GLP-1 through the circulation reach the islet beta retinoic acid receptor to stimulate their se

• Saururus chinensis Lour Baill Saururaceae a perennial herb i

  2021-03-22

  

  Saururus chinensis (Lour.) Baill. (Saururaceae), a perennial herb, is widely cultivated in China and southern Korea. It has been traditionally used as folk medicine for the treatment of inflammation, jaundice and gonorrhea [8]. Previous chemical studies of S. chinensis have revealed the presence of

• br Results and discussion br Conclusions An optimization

  2021-03-22

  

  Results and discussion Conclusions An optimization study of the dipeptidyl enoates was performed by chemical structure modifications (Fig. 5). Compound FGA50 displaying R configuration at C-3 was more active than its epimer FGA40. Two modifications of the chemical structure of FGA50 were done:

• Proteolysis by CPs is crucially important for cereal

  2021-03-22

  

  Proteolysis by CPs is crucially important for cereal seed development and germination. However, these enzymes must be tightly controlled. Pre-harvest sprouting is a phenomenon in which the control of CPs is disrupted. This disruption manifests in the premature synthesis and activation of CPs, leadin

• Naringenin is the one of the many

  2021-03-22

  

  Naringenin is the one of the many components in grapefruit juice. It was assumed that administration of 20mL grapefruit juice per kilogram of body weight is completely glucuronidated in the hepatic or gut wall for first pass metabolism [38]. It has been detected that one liter of grapefruit juice co

• br Neuroimaging Neuroimaging has not yet been

  2021-03-22

  

  Neuroimaging Neuroimaging has not yet been systematically reported in individuals with CDD, although case reports document normal Cucurbitacin I receptor anatomy or less often, show cortical atrophy or T2 fluid-attenuated inversion recovery hyperintensities in the white matter.15, 17, 18, 19, 48

• Multiple lines of evidence now indicate that mitochondrial d

  2021-03-22

  

  Multiple lines of evidence now indicate that mitochondrial decay is a fundamental factor that leads to alterations in energy metabolism in the aged heart (Hagen et al., 2002, Judge and Leeuwenburgh, 2007, Lesnefsky et al., 2001c). Nevertheless, the exact biochemical events that cause such an alterat

• br Introduction br Multiple levels of CK AKT

  2021-03-22

  

  Introduction Multiple levels of CK2/AKT cross-talk Isoform-specific signaling in CK2/AKT cross-talk Particularly relevant to the scope of this review, it has been shown that depletion of the CK2 catalytic α′ subunit is more effective than that of the α subunit at reducing AKT Ser129 phospho

• Being a rare renal tumor

  2021-03-22

  

  Being a rare renal tumor, its description as primary renal tumor has been confined to the documentation of anecdotal case reports in the past [4], [9], [10], [11]. However, recent years have seen an increased interest in defining ES/PNET of kidney as a distinct entity, with the study undertaken by t

• br O GlcNAc transferase OGT belongs to

  2021-03-19

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• Recent reports revealed that CSE affects the endothelial cel

  2021-03-19

  

  Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including sch d [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of inflammatory

• CXCR is not only critical in the B cell lineage

  2021-03-19

  

  CXCR5 is not only critical in the B cell lineage in FL. A high proportion of CXCR5-expressing follicular helper T cells (TFH) were observed in FL but not in closely related DLBCL [141] and further investigation revealed that FL regulatory T cells (Tregs) used a CXCL13-CXCR5 autocrine loop for positi

• DNA replication checkpoint kinases in

  2021-03-19

  

  DNA replication checkpoint kinases in both yeast and human Kifunensine upregulate dNTP levels under replication stress to mediate their essential function at replication forks (Yeeles et al., 2013). It is possible that upregulation of dNTP levels under replication stress helps fork restart once rep

• br Phenotypic responses alkylation induced cell death and mu

  2021-03-19

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• It is well established that p maintains genomic

  2021-03-19

  

  It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause NPE-caged-proton receptor arrest and to repair cellular damage. Ther

14971 records 610/999 page Previous Next First page 上5页 606607608609610 下5页 Last page