• It is important to note that histamine

  2022-01-17

  

  It is important to note that histamine H1 and H2 receptors are coupled to different G proteins and that their crossinterference induced by histamine H1 and H2 receptor inverse agonists depends on the cointernalization mechanism. To date, histamine H1 and H2 receptor inverse agonist have shown to int

• br The glyoxalase system has not yet been

  2022-01-17

  

  The glyoxalase system has not yet been studied in E. histolytica or G. lamblia. Searches in the G. lamblia genome (GiardiaDB.org) revealed two genes encoding hydroxyacylglutathione hydrolases (Morrison et al., 2007), but no glyoxalase I gene was found. The genome of E. histolytica does not have a

• The current study also inferred that MT content

  2022-01-17

  

  The current study also inferred that MT content in Crassostrea gigas might be associated with the Cd level, and can be affected by MT turnover. The Pazopanib of MT in cytosol is beneficial for aquatic organisms to adapt the seawater contaminated by heavy metals, and MT is a biomarker for marine inv

• br Discussion In the present study we have demonstrated the

  2022-01-17

  

  Discussion In the present study, we have demonstrated the effect of a high-fat diet upon wild-type and glut3 pregestational female phenotype and shown that it leads to obesity due to an increase in white adipose tissue contributing to the overall fat mass. Despite this observed obesity along with

• br Mechanisms of action Ghrelin

  2022-01-17

  

  Mechanisms of action Ghrelin is a 28-amino W146 peptide hormone primarily produced in the oxyntic mucosa of stomach, but also in other gastrointestinal tissues [7] (Fig. 1). It acts as the endogenous ligand for the ghrelin receptor [GHS-R1a] and causes the release of growth hormone from the pitu

• Cx has been shown to be serine phosphorylated by

  2022-01-17

  

  Cx45 has been shown to be serine phosphorylated by CaMKII, CK1, PKA, and MAPK in HeLa Ruxolitinib phosphate sale [77], [78]. Phosphorylation by PKA and MAPK were associated with decreased junctional conductance [78], suggesting that phosphorylation of Cx45 may influence conduction properties. Overa

• The role of GJs in

  2022-01-17

  

  The role of GJs in liver fibrogenesis was studied recently. Studies showed a significant decrease in liver fibrosis in Cx32 knockout mice compared to wild-type mice. Although the mechanism underlying this protective effect of Cx32 deletion is not clear, reduced oxidative stress was suggested as a po

• GLP is released in response to ingestion of

  2022-01-17

  

  GLP-1 is released in response to ingestion of nutrients including carbohydrates, protein, and fat. Recent studies aimed at identifying the receptors involved in nutrient stimulated GLP-1 secretion have identified free fatty Cilengitide receptor 4 (FFA4/GPR120) as a potential 7TM receptor involved in

• Signaling pathways such as BMP FGF and WNT are strongly

  2022-01-15

  

  Signaling pathways such as BMP, FGF, and WNT are strongly involved in the process of endochondral ossification and Meckel's cartilage development [20]. Interestingly, absence of BMP antagonist, Noggin, in Meckel's cartilage, resulted in a phenotype, very similar to that of Setdb1 CKO [16]. To examin

• To further investigate the molecular

  2022-01-15

  

  To further investigate the molecular mechanisms that underlie glycine's β-cell protective effects through its antioxidative activity in diabetes, we used a H2O2/high glucose-induced apoptosis cell model. Similar effects on ROS generation of high glucose and H2O2 support the in vivo results, suggesti

• Excessive extracellular glutamate may induce excitotoxic neu

  2022-01-15

  

  Excessive extracellular glutamate may induce excitotoxic neuronal damage in disorders of the CNS (Schwartz et al., 2003). EAATs are considered to contribute to prevention of excitotoxicity by glutamate uptake. Our data revealed that expression levels of membrane EAAT proteins in astrocytes are much

• br Genetic rescue of GluR

  2022-01-15

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific AP24534 of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005). This

• In patients with type diabetes glucagon

  2022-01-15

  

  In patients with type 2 diabetes glucagon receptor antagonism led lowered fasting glucose however not postprandial glucose levels [9], which may reflect that glucagon may not be of particular importance for the diabetic hyperglycemia upon a meal. Current glucagon receptor antagonists have however be

• It is widely acknowledged that a

  2022-01-15

  

  It is widely acknowledged that a significant gap exists between the increasingly detailed knowledge of subcellular mechanisms and the ability to control large-scale anatomy. Radical advances in regenerative medicine require approaches aimed at taming the fundamental complexity of cellular regulation

• Although GABA C receptors were originally

  2022-01-15

  

  Although, GABA-C receptors were originally described in the spinal cord [16], clues to their physiological function arise mainly from studies in the visual system [5], [26]. In mammals, GABA-C receptors are found abundantly in cone photoreceptors and bipolar cell axon terminals, where they participa

14971 records 432/999 page Previous Next First page 上5页 431432433434435 下5页 Last page