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coelenterazine The first objective of the present study was
2023-09-11

The first objective of the present study was to investigate the impact of ageing on arginase activity in tissues which exhibit age-related impairments in their function. The second objective was to determine whether l-arginine supplementation modulated the effect of ageing on arginase activity. The
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Introduction Hepatocellular carcinoma HCC is one of the
2023-09-11

Introduction Hepatocellular carcinoma (HCC) is one of the most difficult cancers to treat, and it threatens human health severely [1]. Although various interventions, including surgical operation, radiofrequency ablation, and chemotherapy, have been endorsed, the prognosis of HCC patients remains p
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The current literature clearly states that there
2023-09-11

The current literature clearly states that there are no widely adopted standardized methods to determine the total antioxidant capacity of foods or biological samples. One should consider the antioxidant reaction mechanism in system to determine the most appropriate methods for the measurement. It h
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br Materials and methods br Results and
2023-09-09

Materials and methods Results and discussion Conclusion The preparation of acrylic nanoparticles as aminosugar carriers could not be achieved by direct functionalization of poly(t-butyl acrylate) particles with saccharide groups. A four-step procedure starting from a protected derivative of
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Given that the FST protocol for mice does not engage
2023-09-09

Given that the FST protocol for mice does not engage the exposure to a previous stressful session, posits that Agtr1a levels could be kept higher by basal glutamatergic transmission rather than by stressful stimuli as postulated before. To address this possibility, we used the EMBL-EBI Expression At
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Luo Dehm Raj Luo Attard Balk
2023-09-09

Luo, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong, Gao, Gleave, Heemers, Kanayama, Kittler, Lang, Lee, Logothetis, Matusik, Plymate, Sawyers, Selth, Soule, Tilley, Weigel, Zoubeidi, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong,
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br Expression of adiponectin mRNA in
2023-09-09

Expression of adiponectin mRNA in chickens We first sought to determine the nucleotide sequence of the chicken adiponectin cDNA. The open reading frame of the chicken adiponectin cDNA consists of 735 nucleotides that was 65–68% homologous to various mammalian adiponectin cDNAs (Maddineni et al.,
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br ACh and ER tests
2023-09-09

ACh and ER tests hereafter Spasm provocation tests have self-limitations to document coronary artery spasm during daily life. In the past reports, ST elevation was reproducible in some patients with variant Silodosin mg by the administration of ACh or ER. However, we now employ the ER and ACh sp
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MafB a member of the Maf protein family is
2023-09-09

MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in Oxaliplatin with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages
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By performing knockdown of AXL once HER cancer cells
2023-09-09

By performing knockdown of AXL once HER2+ cancer Pifithrin-μ have achieved lung colonization, we demonstrated that AXL contributes to the establishment of macrometastases. While inhibition of AXL impairs the efficiency of metastasis, the later finding has major clinical implications since pharmacol
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The identification of novel kinase inhibitor scaffolds is hi
2023-09-09

The identification of novel kinase inhibitor scaffolds is highly desirable in order to develop selective kinase inhibitors. Small-molecule inhibitors of Interleukin-2-inducible T-cell kinase (Itk) that are based on the 3-aminopyridin-2-one fragment 1 have been reported. Despite derivatisation of 1 y
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To further address the mechanism
2023-09-08

To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor AP-III-a4 receptor and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurri
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br Discussion In a series
2023-09-08

Discussion In a series of linear mixed effects models of longitudinal neuroanatomical change, we have identified genetic risk variants associated with an increase in Splitomicin shape asymmetry in AD. The closest genes associated with significant SNPs include BIN1 (rs6733839), CD2AP (rs10948363)
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Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A
2023-09-08

Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in
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The overall adjustment the non
2023-09-08

The overall adjustment, the non-toxicity and the addiction-free treatment methods are the advantages of EA. EA treatment for depression has achieved great clinical effect in recent years (Dong et al., 2017). The clinical practice guideline of the American college of physicians (ACP) have pointed out
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