• br Problem setting PS M V a presenilin model implying

  2018-11-14

  

  Problem setting PS1-M146V, a presenilin model implying the presence of a mutation in the gene encoding the presenilin protein [7]; APPKI, an amyloid model implying the presence of a mutation in the gene encoding APP [9]. Recently, our laboratory has developed one more model which, in reverse tr

• The first bleeding risk prediction

  2018-11-14

  

  The first bleeding risk prediction score (ORBI score) was published in 1998 and it was developed in patients newly started on warfarin after hospitalisation for venous thromboembolism (Beyth et al., 1998). Since then various bleeding risk scores have been described but only four (HAEMORR2AGES (Gage

• br Discussion Standardized case ascertainment based on pre d

  2018-11-14

  

  Discussion Standardized case ascertainment based on pre-defined case definitions has been shown to be reproducible and consistent (Rath et al., 2010; Muehlhans et al., 2012). The retrospective classification of clinical cases however, is often challenged by missing data in medical records, thus l

• br CRISPR Cas Tips and Tricks

  2018-11-14

  

  CRISPR Cas9 Tips and Tricks Dario Lupianez and Malte Spielmann (Berlin, Germany) held an engaging workshop titled CRISPR Cas9 tips and tricks. The aim was to demonstrate how this genome editing technology can be utilized in embryonic stem TASIN-1 (ESCs) to produce genomic structural variations (

• The authors addressed this question using a meta analytic

  2018-11-14

  

  The authors addressed this question using a meta-analytic approach involving 15 studies that examined more than 12,000 smokers (). The study found that there were no differences in the benefits of quitting based on CHRNA5 allelic status. Consistent with many previous studies the benefits of quitting

• There are additional important noteworthy points Although

  2018-11-14

  

  There are additional important noteworthy points. Although both retinal pigment epithelial tsa inhibitor (RPE) and endothelial cells showed glucose induced reduction of miR15a and associated alteration, overexpression of miR15a in the endothelial cells (as Tie2 is not expressed in the RPE) prevente

• The observation of increases in plasma BPG in the

  2018-11-14

  

  The observation of increases in plasma 2,3-BPG in the TBI patients, which was unrelated to the patient outcome, is difficult to interpret for two reasons. First, blood concentrations of 2,3-BPG are dominated by the concentration of this metabolite in red blood cells (RBCs), where it acts as an allos

• Potential associations between epigenetic regulation of

  2018-11-14

  

  Potential associations between epigenetic regulation of HPA axis genes and clinical outcomes still remain relatively unmapped, as only DNA methylation of NR3C1, HSD11β2, and FKBP5 has been studied in direct relation to risk for any human disease, with the majority of research focusing on epigenetic

• BCG has been integrated into the Expanded Immunization

  2018-11-14

  

  BCG has been integrated into the Expanded Immunization Program of WHO since 1974 and neonatal vaccination with BCG is still used to prevent TB in countries with a high burden of TB (Marais et al., 2016). Correspondingly, adolescents and adults with LTBI always occur epidemiologically following inocu

• br Discussion Genome wide analyses of the mammalian

  2018-11-14

  

  Discussion Genome-wide analyses of the mammalian transcriptome revealed that lncRNAs is pervasively transcribed in the genome and accumulating studies have demonstrated that lncRNAs as novel regulatory molecule plays critical roles in mammalian development [1,2], but little is known about the pot

• br Value of the data br Experimental design

  2018-11-14

  

  Value of the data Experimental design, materials and methods Specifications table Value of the data Data, experimental design, materials and methods Materials and methods Data In summary, a total of 74,433 peptides corresponding to 9247 protein groups were identified as the new vers

• Recent research has highlighted the role of callous unemotio

  2018-11-13

  

  Recent research has highlighted the role of callous-unemotional (CU) traits, characterised by a lack of guilt, remorse and empathy, in increased risk for persistent antisocial behaviour and adult psychopathy (Barry et al., 2000; Frick et al., 2003; Viding, 2004; Frick and White, 2008; Frick et al.,

• Sobre su cuerpo reca a as el peso

  2018-11-13

  

  Sobre su cuerpo recaía así el peso de la ley: clínicamente, Guadalupe Vargas podía ser apta para el acto del coito, pero, por tener una sexualidad ambigua, el matrimonio le estaba prohibido: “[e]l doble eunuquismo THZ1 que la naturaleza condena a los hermafroditas (salvo una que otra rarísima excepc

• or Previous evidences indicate that EDS

  2018-11-13

  

  Previous evidences indicate that EDS and SOS episodes have a different pattern of manifestation in PD. For instance, EDS is frequently found [7]; otherwise, SOS is less common and manifests somewhat similar to narcoleptic events [8]. Of note, the extent and severity of SOS in PD is variable: some pa

• In Weinstock and Walters of

  2018-11-13

  

  In Weinstock and Walters [8], 43% of RLS-associated conditions have also been associated with systemic iron deficiency. Iron is distributed heterogeneously in different regions and congo red cells; brain iron homeostasis is required for its normal function [9]. Iron deficiency is undoubtedly the mo

15785 records 1030/1053 page Previous Next First page 上5页 10261027102810291030 下5页 Last page