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Our western blotting results showed that phospho DDR levels
2020-01-14
Our western blotting results showed that phospho-DDR1 levels continued to increase after I/R injury, and the overall activation trend between phospho-DDR1 and MMP-9 was the same. We found that phospho-DDR1 expression started to increase significantly at 12h after I/R injury, which may be related to
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Fujimoto et al pointed out that RPN knockout alleviated
2020-01-14
Fujimoto et al. pointed out that RPN2 knockout alleviated the resistance of GC Cefepime Dihydrochloride Monohydrate receptor (MKN74 and KATO III) to docetaxel and DDP [23]. Yuan et al. demonstrated that the depletion of RPN2 resulted in the reduction in resistance of GC cells to drugs such as irino
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Several studies have shown that independently
2020-01-14
Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma
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Enzyme mimics belong to a type of rising
2020-01-14
Enzyme mimics belong to a type of rising catalysts which show the similar function with their corresponding natural enzymes [20], [21], [22], [23], [24], [25], [26], [27], although their structures are different from natural enzymes. In the area of prodrug activation, the widely-used enzyme mimics
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We postulate that OT contained in milk during early
2020-01-14
We postulate that OT contained in milk during early postnatal development causes a mild enteroprotective preconditioning of the ER (Fig 9). This is perhaps akin to a mechanism shown by others [50], [51], [52], which is characterized by selective activation of the IRE1a/XBP1/eIF2a (via PKR) UPR pathw
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The identification of CCR B cells within the LZ
2020-01-14
The identification of CCR6+ Hexa His tag within the LZ as direct progenitors of MBCs provides a new window into the evolution of immune responses. In practical terms, flow-cytometric detection of CCR6+ GC B cells could provide a means of rapidly assessing vaccine efficacy when applied to fine needle
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These studies suggested that PV PVH might
2020-01-14
These studies suggested that PV/PVH might promote bone formation activities and/or inhibit bone resorption activities probably due to its anti-inflammation activity; however, the underlying mechanism remained unknown. Furthermore, it is unclear if PVH shows better activity than that of PV; this is i
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Predictions of enzyme topology for DGAT are more difficult s
2020-01-13
Predictions of enzyme topology for DGAT2 are more difficult since the DGAT2 polypeptide sequences are more diverse across species than those of DGAT1. The length and function of the hydrophilic N-terminus preceding the first hydrophobic segment varies with species – for example, segments in fungi ar
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Phylogenetic analysis indicates that in poikilothermic verte
2020-01-13
Phylogenetic analysis indicates that in poikilothermic vertebrates CXCR3a and CXCR3b have evolved independently from a common gene possibly after the 2nd round whole genome duplication but before the split of bony fish and tetrapods (Fig. 1 and Supplementary file 3). Owing to the extra round of whol
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The radial distribution function is
2020-01-13
The radial distribution function, , is given by: For pure components and pseudo-components, the constants a and b are calculated as:whereand Tc, Pc and ω are the critical temperature, critical pressure and acentric factor, respectively. Parameters a and b for mixtures are calculated from those of
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Introduction Breast cancer is a
2020-01-13
Introduction Breast cancer is a highly prevalent malignancy. There are some recognized risk factors for breast cancer, like early menarche or late menopause, which increase the length of the exposure to hormones, as a result of a higher number of ovarian cycles [1]. Moreover, there is evidence supp
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EphB promotes tumor growth by stimulating angiogenesis throu
2020-01-13
EphB4 promotes tumor growth by stimulating angiogenesis through EphrinB2 [18]. However, the distinct and specifically involvement of Benzoylmesaconitine sale and veins in the tumor angiogenesis of all tumor grades is unclear. Our results indicate that the relation between EphrinB2 and EphB4 stained
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To study systemic potential of the selected
2020-01-13
To study systemic potential of the selected compounds as EP1 receptor antagonist, they were evaluated with regard to the sulprostane-induced increase of intravesical bladder pressure in rats. Some of the analogs, 13 and 15–17, which were selected on the basis of their in vitro EP1 receptor affinity,
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Since the dideoxy analogues and served
2020-01-13
Since the 1,2-dideoxy analogues, and , served as substrates for TgTCEA and TgTCEB, respectively, with the higher affinity (lower ) and lower turnover number (lower ) than their authentic substrates, PosA and PosB (such trend was more evident on analogue for TgTCEB than on analog for TgTCEA), an intr
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In this study we generated mice in which the native
2020-01-13
In this study we generated mice in which the native Bcl6 locus was engineered to produce a form of Bcl6 containing a mutant RD2 domain that disrupts its repressor function. We found that RD2 domain is essential for pre-GC B cell differentiation and clustering into nascent GC within follicles, in par
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