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Confirmation of the presence of H
2020-07-30
Confirmation of the presence of H+-PPase genes in the genomes of the different protists tested was obtained by Southern blot analyses using the PCR-amplified DNA fragments as probes (Fig. 3). In the trypanosomatids L. major and T. cruzi and the euglenoid A. longa, a single band appeared in the filte
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Another potential use for CDK inhibitors in CLL is in
2020-07-30
Another potential use for CDK inhibitors in CLL is in the context of lymphocytosis that has plateaued during treatment with a BCR pathway inhibitor. Although it has recently been shown that patients with prolonged lymphocytosis following achievement of PR with lymphocytosis (PR-L) do not fare more p
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With the narrow SAR of
2020-07-30
With the narrow SAR of the tail favouring the ortho sulfone group, we examined the remaining position open to substitution at the pyrazole 3-position, in an attempt to at least moderate the excessive human PPB (). Lipophilic groups in this position maintained huge shifts in potency in the absence or
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The temporal data for the
2020-07-30
The temporal data for the effect of antisauvagine-30 pretreatment on urocortin 2 (0.1 mg kg −1) evoked changes in mean arterial blood pressure are shown in Fig. 3. The systemic administration of urocortin 2 (0.1 mg kg−1) at 30 min produced a significant reduction in mean arterial blood pressure when
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It is well established that
2020-07-30
It is well established that CRF action is triggered by its binding to CRF1 or CRF2, two G protein-coupled receptors (GPCR). Perhaps the principal or best-known action mechanism following activation of both CRF receptors is through stimulatory G protein activation (GsP), which in turn stimulates the
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1664 mg br Experimental br Acknowledgments br Phylogenetic
2020-07-30
Experimental Acknowledgments Phylogenetic analysis was carried out within the framework of the institutional research project (no. 01201255617) of the Komarov Botanical Institute of the Russian Academy of Sciences. Financial support was provided in part by the Russian Foundation for Basic Re
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A surprising second functional effect was found in culture
2020-07-29
A surprising second functional effect was found in culture experiments. Inclusion of LTD4 reduced the frequency of Fas receptor (CD95) expression. Once again, this effect, although modest, was reversed by a cysLT1 receptor antagonist. The biologic significance of this effect or its mechanism remaine
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Taken together this study gives first insights into the comp
2020-07-29
Taken together, this study gives first insights into the complex effect of DNMT inhibition on pattern separation. Acute administration of RG108 enhanced pattern separation performance measured with the OPS task and increased Bdnf1 expression. However, this effect was only acute, and was not present
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The chemokine receptor CXCR plays a
2020-07-28
The chemokine receptor CXCR5 plays a significant role in CLL/SLL pathogenesis. The receptor protein has been identified on greater than 90% of patient samples [3], [4], [10], [72] and shown not to be affected by IGHV mutation status [90]. Depending on the study, CXCR5 protein was either similarly ex
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p is activated in response to several malignancy associated
2020-07-28
p53 is activated in response to several malignancy-associated stress signals, giving rise to the inhibition of tumor cell growth (Garritano et al., 2013). Several responses can be elicited by p53, including Brefeldin A arrest, senescence, differentiation and apoptosis. The p53 protein is controlled
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Adenosine is a naturally occurring
2020-07-28
Adenosine is a naturally occurring purine nucleoside that is distributed ubiquitously throughout the body as a metabolic intermediary. In the brain, adenosine functions as an important upstream neuromodulator of a broad spectrum of neurotransmitters, receptors and signaling pathways. By acting throu
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Funding sources This study was funded by
2020-07-28
Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg
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br Materials and methods br Results br
2020-07-28
Materials and methods Results Discussion The serine/threonine kinase DAPK plays an important role in a wide range of different cell death modes (Lin et al., 2010). To date, only a limited number of proteins that interact with DAPK have been identified. Recently, we have described a novel in
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CRF dependent sensitization of VTA
2020-07-28
CRF-dependent sensitization of VTA glutamate release after repeated administration of cocaine has also been documented in an electrophysiological study recording from glutamatergic synapses in VTA containing slices from mice repeatedly treated with cocaine [44]. In this case, both pre and postsynapt
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The importance of mitochondria as site
2020-07-28
The importance of mitochondria as site of aerobic oxidation of metabolic fuels, such as FA, has been recognized for a long time. It has been observed that the number of mitochondria may vary in response to cellular metabolic requirements and hormonal environment (Gao et al., 2014). In order to susta
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