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As noted by the authors a limitation
2020-08-03
As noted by the authors, a limitation of this study is that alternative activation of CPT1a-deficient macrophages was only assessed in vitro. An important question is how macrophage-specific CPT1a-deficient mice behave in vivo in situations like asthma, helminth infections, wound healing, and tumors
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br Conclusions and future work Our approach
2020-08-03
Conclusions and future work Our approach proposes the use of another DSL to specify components. Thus, the possible application domains are restricted to those software architectures built from components that meet our component definition. We call our type of component COTSget, from the combinati
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We have identified a member of the
2020-08-03
We have identified a member of the ACC-1 family in the parasitic nematode H. contortus and investigated its binding site using site-directed mutagenesis, homology modelling and pharmacological analysis. This family of receptors appear to be unique to invertebrates and not present in mammals, making
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Berner et al used a
2020-08-03
Berner et al used a meta-analysis to show that sildenafil resulted in an effect of 9.65-point improvement. Tadalafil could be pooled into an effect of 8.52-point improvement, and vardenafil showed an effect of 7.50-point improvement. In our present studies, 200 mg udenafil resulted in an effect of 8
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br Funding This work was supported
2020-08-03
Funding This work was supported by the grants from MSD, Terumo Life Science Foundation, Takeda Science Foundation, and Japan Diabetes Foundation. Disclosures Acknowledgments The authors thank C. Morimoto (Juntendo University, Tokyo, Japan) and K. Takeda (Immunology Frontier Research Center
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Here we uncover a highly
2020-08-03
Here we uncover a highly diverse superfamily of self-replicating MGEs, dubbed pipolins, which are present in three major bacterial phyla, as well as in mitochondria, and encode divergent PolB carrying TPR1 and TPR2 subdomains. Biochemical characterization of a representative enzyme encoded by a pipo
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Various features can be assessed to estimate quality and
2020-08-03
Various features can be assessed to estimate quality and function of poultry spermatozoa including concentration, motility, morphology, viability, metabolism, lipid peroxidation, and ability of spermatozoa to bind and penetrate the perivitelline layer (Bakst and Cecil, 1997). Nevertheless, many tech
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In the first step the ATP cofactor is locked
2020-08-03
In the first step, the ATP cofactor is locked into the enzyme’s active pocket where the ε-amino group of the lysine residue (e.g. Lys-238 in Enterobacteria phage T7) attacks the α-phosphorus XEN445 mg of ATP to form, in an SN2P substitution reaction [4], the AMP-NH2-ligase intermediate, with simulta
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Leukotrienes the products generated by the lipoxygenase path
2020-08-03
Leukotrienes, the products generated by the 5-lipoxygenase pathway, are a family of lipid mediators involved in the pathogenesis of WZ3146 and allergy. Leukotrienes increase microvascular permeability and are potent chemotactic agents (Wallace et al., 1989). Cysteinyl leukotrienes, namely leukotrie
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Currently there is no direct evidence of an association betw
2020-07-31
Currently, there is no direct evidence of an association between DBP exposure and the ERK 1/2 pathway. However, numerous different stimuli, including ROS accumulation and excessive Ca2+, can activate the ERKs pathway (Mccubrey et al., 2006; Kemmerling et al., 2007). The ERK family comprises five sub
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br EBI An Endogenous TM
2020-07-31
EBI2: An Endogenous 7TM Receptor Manipulated by EBV EBI2 was identified in 1993, when Kieff and colleagues used subtractive hybridization of DNA from Burkitt\'s lymphoma cells to screen for upregulated genes in EBV-infected cells. They found, being more than 200-fold upregulated (hence the name:
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A general mechanism for the oxidation
2020-07-31
A general mechanism for the oxidation of NOHG can be proposed on the basis of previously published mechanisms. One-electron oxidation of the NOHG moiety by Cu(II) generates an iminoxyl radical (Scheme 2) that can undergo dimerisation, either through a N–N coupling (Scheme 2, pathway (a) forming a N-
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br Materials and methods br Results and discussion In E
2020-07-31
Materials and methods Results and discussion In E. coli, exposure to the DNA-alkylating agents induces an increase in Fmoc-Hyp-OH of four DNA repair genes, namely, alkA, alkB, aidB and ada, which are regulated by the Ada protein and collectively called ‘ada regulon’ [22]. In E. coli, ada and a
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Our previous data showed that microsomal
2020-07-30
Our previous data showed that microsomal VgDGATs have higher specificity for acyl substrates containing Va (Yu et al., 2006). Here, analysis of lipid Aloperine in transgenic soybean seeds and Stokesia and Vernonia seeds demonstrated that the Va-PC level is higher while Va-TAG is lower in the SlEPX-
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Stimulation of the VSMC with Ang II also
2020-07-30
Stimulation of the VSMC with Ang II also resulted in a time-dependent decrease in gp130-related mRNA but the maximal decrease occurred four hours after stimulation and level remained markedly low within 12 hours after stimulation . Again, our results show that stimulation of the VSMCs with Ang II fo
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