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br Study design br Results To
2020-12-17
Study design Results To explore potential differences in the volume the different swabs absorb, the loss of weight of tubes filled with water after soaking the different swabs under defined conditions was determined. This revealed that the different swabs absorbed between approximately 0.07 an
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Early studies from the mollusk Aplysia reported the presence
2020-12-17
Early studies from the mollusk, Aplysia, reported the presence of a unique class of risedronic acid sale receptors in neurons, the acetylcholine-gated chloride channels (ACCs) (Kehoe and McIntosh, 1998). Later, studies identified these receptors in the model nematode Caenorhabditis elegans (Putrenko
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At one time the biological
2020-12-17
At one time, the biological effects of cAMP were thought to be mediated exclusively by Protein Kinase A (PKA). Consistent with this, PKA inhibitors have been shown to reverse the effects of cAMP-elevating agents on VSMC proliferation [5]. However, we recently reported that cAMP-mediated inhibition o
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br Physiological roles for EPAC isoforms vascular function T
2020-12-17
Physiological roles for EPAC isoforms: vascular function The effects of cAMP on limiting vascular endothelial cell (VEC) inflammation and vascular smooth muscle cell (VSMC) proliferation have been well documented 36, 37, 38. However, recent work has demonstrated that several key effects of cAMP i
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Quinacrine hydrochloride hydrate Nitric oxide synthase NOS i
2020-12-17
Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino Quinacrine hydrochloride hydrate arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, among an
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It is noteworthy that little is known
2020-12-17
It is noteworthy that little is known as to the role of autophagy in regulation of eNOS phosphorylation and eNOS uncoupling. eNOS monomers, but not eNOS dimers could be degraded by ubiquitination [39], harbingering the existence of protein degradation pathways in modulation of eNOS turnover and acti
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br Transparency document br Introduction Cigarette smoke
2020-12-17
Transparency document Introduction Cigarette smoke is modifiable factors to alter the neurovascular functions. Now a day, cigarette smoking in public place is offense due to toxic exposure cause the neurological and respiratory system damage to non-smoker population [1]. A literature survey ex
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A structural explanation for how RBR RING
2020-12-16
A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon
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ATP dependent DNA ligases in
2020-12-16
ATP-dependent DNA ligases in vertebrates are divided in three families [7]. Family I DNA ligases are responsible for sealing the nicks during DNA replication and in long-patch base excision repair (BER). Family III DNA ligases are involved in short-patch BER. Lastly, family IV DNA ligases are involv
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The present study was set to characterise the DNMT
2020-12-16
The present study was set to characterise the DNMT gene orthologs and describe the expression patterns of these genes during seed development in natural diploid apomict B. divaricarpa and diploid sexual B. stricta. Material and methods Results The B. stricta genome v1.2, was sequenced and ass
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DGAT-1 inhibitor br Materials and Methods br
2020-12-16
Materials and Methods Results Discussion HSCs have been identified as major collagen-producing DGAT-1 inhibitor in the injured liver (1), and activation of HSCs has become the central link for liver fibrosis (2). The factors that regulate the biological behavior of HSCs include soluble reg
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Taken together our results demonstrate that the changes of
2020-12-16
Taken together, our results demonstrate that the changes of striatal dopamine release and locomotor activity observed following chronic nicotine treatment and consequent acute withdrawal are mediated by CRF1, but not CRF2. Previous studies have already indicated that blocking CRF1 would prevent some
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Previous studies from our laboratory in
2020-12-16
Previous studies from our laboratory in CD1 mice using the incisional postoperative pain model have shown that the incision induces significant mechanical postoperative hyperalgesia lasting between 7 and 10days, with peak effect between 4h-2days (Cabañero et al., 2009a, Cabañero et al., 2009b, Campi
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Sensory gating describes a filter mechanism
2020-12-15
‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits Trigonelline to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). Audit
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For the first time we
2020-12-15
For the first time, we provide evidence for COMT Val158Met modulation of long-term fear extinction in humans, evident both in cortical (LPP) and autonomic (fear bradycardia) components of the conditioned fear response. We further found that the initial acquisition of fear is related to dispositional
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