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In the present study we first examined the in vivo
2021-02-15
In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 ZM 447439 mg in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and meth
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br O GlcNAc transferase OGT belongs to
2021-02-15
O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t
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Dabrafenib br Results br Discussion The ubiquitin system
2021-02-12
Results Discussion The ubiquitin system has in recent years become an exciting area for drug discovery (Cohen and Tcherpakov, 2010), as multiple enzymatic steps within the ubiquitylation process are druggable. The potential of targeting the ubiquitin-proteasome pathway was first demonstrated i
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br Methods for assessing TLS While
2021-02-12
Methods for assessing TLS While the precise quantification of restricted DNA synthesis events is possible (e.g. unscheduled DNA synthesis (UDS) reveals NER), so far, it is impossible to identify TLS stretches of only a few nucleotides within the background of bulk DNA replication of normal DNA. N
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The phenotypes of KD Ddr transgenic mice were less
2021-02-12
The phenotypes of KD-Ddr2 transgenic mice were less severe than expected from the results of miDdr2-transfected ATDC5 cells, which indicated that DDR2 might play important roles in endochondral ossification but neither critical nor essential roles in determining total body and skeleton size. The gr
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Interaction between neutrophils and ECs represents the first
2021-02-11
Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that
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In conclusion high methylation levels of CDKL were
2021-02-11
In conclusion, high methylation levels of CDKL2 were observed both in HCC cell lines and tissues, which showed a negative association with mRNA expression. Moreover, treatment with demethylation agent in HCC cell lines could upregulate CDKL2 mRNA expression. The discovery of the epigenetic modificat
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br Clinical trials of CRM
2021-02-11
Clinical trials of CRM1 inhibitors KPT-330 clinical trials have been initiated with promising very early results. One trial includes patients with advanced solid tumors whose disease has progressed after at least one prior therapy for metastatic disease (NCT01607905). Another trial includes patie
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br Experimental Procedures br Author Contributions H
2021-02-11
Experimental Procedures Author Contributions H.G. and X.-Y.F. conceived and designed the project. H.G., D.V.D., and X.L. performed most of the experiments and analyzed the data. L.X. helped on Mettl8 KO ESC, RIP, and translational study. Y.S. performed FACS analysis. Y.W. helped with cardiomyo
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In patients with CTEPH ET levels are
2021-02-11
In patients with CTEPH, ET-1 levels are raised and have been shown to fall after PEA surgery [24]. After an acute pulmonary embolism there is obstruction of the pulmonary Fatostatin A synthesis by acute thrombus and elevated levels of ET-1 [28], [30]. Elevated levels of ET-1 have also been observed
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ERK and p MAPK signaling pathways play critical role
2021-02-10
ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma 49 9 (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular signal-regulated kinas
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As for the molecular mechanism Ferguson BD suggested that Ep
2021-02-10
As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of Deferoxamine mesylate with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expr
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br Materials and methods br Results br Discussion
2021-02-10
Materials and methods Results Discussion Studies have suggested that the Hh signaling pathway, which plays as an essential autocrine viability factor for MFBs [10], [11], is a potential therapeutic target for liver fibrosis. Previously reported works have proven the effectiveness of the Hh
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br Introduction A variety of
2021-02-10
Introduction A variety of means, including UV irradiation, dNTP depletion, and oncogene activation at precancerous lesions, induce replication stress, which causes replication errors if left undealt with (Hills and Diffley, 2014, Zeman and Cimprich, 2014). Eukaryotic cells have developed the DNA
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DSBs can be repaired by two
2021-02-10
DSBs can be repaired by two major pathways: canonical non-homologous end-joining (c-NHEJ) and homologous recombination (HR) (Chapman et al., 2012). c-NHEJ comprises two sub-pathways, a resection-independent process and a resection-dependent process, and can rejoin break ends with little or no sequen
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