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We also explored various nitrogen
2021-12-09
We also explored various nitrogen substituents with an aim toward modulating sterics and basicity within the ABH series. No glycine uptake inhibition was detected with non-basic bicycles (data not shown). Isopropyl was the best compromise between desired on-target effect and clearance, however, eff
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Through a large scale phylogenetic analysis of UDG superfami
2021-12-09
Through a large-scale phylogenetic analysis of UDG superfamily in more than 1000 completely sequenced genomes, it is shown that family 3 N1-Methylguanosine-5'-Triphosphate can be separated into two clades with the traditional family 3 SMUG1 as one of them (Fig. 1) [31]. UDG enzymes in another clade
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br Treatment KD is currently
2021-12-09
Treatment KD is currently the treatment of choice for GLUT1-DS. It is a high-fat, carbohydrate-restricted diet that mimics the metabolic state of fasting; so, the KD relies an exogenous rather than body fat for ketone production, thus maintaining ketosis without weight loss. As the developing br
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The role for noggin in telencephalic development and also
2021-12-09
The role for noggin in telencephalic development and also adult neural stem cell expansion and differentiation has been debated, and noggin has been suggested to exert diverse effects in these events (Bachiller et al., 2000, Bonaguidi et al., 2008, Colak et al., 2008; de Chevigny et al., 2008, Li et
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br Materials and methods br Results br Discussion br
2021-12-09
Materials and methods Results Discussion Acknowledgments Introduction As we move into an aging society, there has been a growing interest in neurological disorders [1]. Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) cause cognitive malfunction
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Nano SiO was a kind
2021-12-09
Nano-SiO2 was a kind of versatile material for enzyme immobilization because of its excellent properties, including low cost, lack of toxicity, high stability, large specific surface area and high biocompatibility [10]. After the immobilization on nano-SiO2, the selectivity of enzymatic reactions wo
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Despite the potential promise of both of these
2021-12-09
Despite the potential promise of both of these peptides, such compounds are still susceptible to efficient renal filtration (Emmanouel et al., 1978, Holst, 1991, Deacon et al., 1996). However, numerous studies have demonstrated that fatty SC-10 dervatisation of related regulatory peptides results i
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The development of metabolic stable non
2021-12-09
The development of metabolic stable, non-peptidergic galanin agonists could be the basis to clinical diagnosis and treatment of tumors with high levels of galanin receptor expression like gliomas and pituitary tumors. As for gliomas, penetration of the blood brain barrier by the compounds might be p
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In summary the SAR of a series of
2021-12-09
In summary, the SAR of a series of phenylpropanoic acid-free fatty blt2 receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which afforded robust efficacy i
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The VirScan assay has several advantages over alternative mu
2021-12-09
The VirScan assay has several advantages over alternative multiplex serological assays for peptide discovery. These advantages include quantitative assessment of antibody binding to peptides that span all open reading frames in the HIV genome, including both structural and regulatory proteins; repre
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br Conclusion Our data allow pharmacological discrimination
2021-12-09
Conclusion Our data allow pharmacological discrimination of diverse of H3 14613 mg antagonists that can be linked to their differential efficacy in preclinical and clinical disease settings (Fig. 6). Moreover, we identify the sigma-1 receptor as a common “off target” for H3 antagonists, and that
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Fig summarizes the results for M concentration of
2021-12-09
Fig. 1 summarizes the results for 500 μM concentration of the drugs. Action of histamine is presented for comparison. Both 1-methylhistamine and Nα-methylhistamine strongly potentiated ASIC1a responses. The concentration-dependence of action of Nα-methylhistamine was measured (Fig. 1B). Fitting by H
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Limited efforts were made to exploit the
2021-12-08
Limited efforts were made to exploit the naturally-occurring antigen-specific Treg for ex vivo expansion. This study sets up a reproducible protocol for the expansion of insulin-specific Treg isolated from NOD mice. These Pam2CSK4 exhibited higher suppressive capacity compared to the polyclonal Tre
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br Materials and methods br Results br Conclusions
2021-12-08
Materials and methods Results Conclusions We developed a glutamate biosensor with chitosan as a matrix for the immobilization of the enzyme glutamate oxidase on the surface of a platinum electrode. Our miniaturized biosensor of 50 µm in diameter can be applied for monitoring glutamate in vi
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br Materials and methods br Results br
2021-12-08
Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the trans-4-Hydroxycrotonic acid rec
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