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Brain derived neurotrophic factor BDNF
2022-05-09
Brain-derived neurotrophic factor (BDNF) is the most abundant growth factor in the brain and is critical for neuronal development and synaptic plasticity (Bekinschtein et al., 2008; Lu et al., 2014). Besides playing an important role in mood and cognition, BDNF is also involved in the regulation of
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We characterized the enzyme corresponding to N FPP was
2022-05-09
We characterized the enzyme corresponding to N1. FPP was the most effective substrate as allylic diphosphate, and the activities with GPP and DMAPP were 50% and 11% that with FPP, respectively. The analysis of the prenols resulting from the treatment of prenyl diphosphates with 143 93 phosphatase (
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In an effort to more fully explore the
2022-05-09
In an effort to more fully explore the structure–activity relationships of the ALLINIs and potentially attenuate resistance to known mutants, the central scaffold of these compounds was identified as a potential site for structural manipulation. Specifically, we wished to examine whether a scaffold
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Our results further indicate that low expression of p
2022-05-09
Our results further indicate that low expression of p300/CBP in CRC is directly associated with poor clinical therapeutic outcome of 5-FU treatment, potentially providing a new set of biomarkers to predict chemo-sensitivity. Although the ability of low expression of p300/CBP to predict poor prognosi
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There were hub genes identified by WGCNA among which
2022-05-09
There were 11 hub genes identified by WGCNA among which KIBRA was the hub gene of the black module. The bioinformatics method is an effective and powerful tool to analyze mRNA Tirapazamine profiles and the related pathways. For instance, the lung cancer risk modules that were closely related to lun
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br Conclusion br Acknowledgments This research was funded by
2022-05-09
Conclusion Acknowledgments This research was funded by Tianjin Health Institution Key Projects, grant number 15KG148” and “Tianjin Medical University General Hospital Youth Incubation Fund, grant number ZYYFY2017029”. I would like to express my heartfelt gratitude to Professor Hongtao Zhang fo
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The nuclear repressor BACH is known to control HO expression
2022-05-09
The nuclear repressor BACH1 is known to control HO-1 expression together with the transcriptional activator NRF2. The results of our study show that HO-1 gene expression in LPS-stimulated macrophages is primarily regulated via BACH1. This idea is supported by a series of experimental evidence demons
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Eastern Guangdong is a Teochew
2022-05-09
Eastern Guangdong is a Teochew dialect area. We found that subtype 1b (3.1%) in this region was significantly lower than in other areas. Subtype 1b began its spread from the central part of China out into the whole country through illegal blood donation in the mid-1990s (Lu et al., 2013) and is now
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The role of the cyclic AMP regulated exchange
2022-05-09
The role of the cyclic AMP regulated exchange factor Epac1 is emerging in cancer (Almahariq et al., 2015, Banerjee and Cheng, 2015, Parnell et al., 2015, Parnell et al., 2015, Schmidt et al., 2013). Interestingly, in cancer cell migration, activation of Epac1 can be linked to activation of Rac. As s
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GW was also the starting point for a
2022-05-07
GW4064 was also the starting point for a study by an independent research group. The co-crystal structure of GW4064 with FXR suggested the potential for favorable hydrogen bond interactions between the isoxazole 3-aryl group and several receptor residues such as Tyr373 and Ser336. Replacing the 2,6-
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br Discussion The pattern of activity exhibited by
2022-05-07
Discussion The pattern of activity exhibited by SSR 504734 and Lu AA21279 in the MEST test was very similar. Both compounds were inactive at the lowest dose (3.0mg/kg), but exhibited robust increases (∼150%) at 10mg/kg followed by a maximal detectable response at 30mg/kg. Based on the magnitude o
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Given that inactivation of GLO by
2022-05-07
Given that inactivation of GLO1 by 4BAB is an active site directed mechanism, as the transition state analogue CHG protects GLO1 against inactivation by 4BAB (Figs. 2D and S6b), we next set out to determine the amino regulator of g protein signaling that is covalently modified by 4BAB. From the X-r
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PTMs have been shown to influence transporter kinetics
2022-05-07
PTMs have been shown to influence transporter kinetics, both directly and indirectly (Xu & You, 2017). They do not just regulate the innate structure-function relationship driven by a transporter's global architecture, but rather are also able to regulate this relationship down to the resolution of
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br Endogenous lipids as SLC
2022-05-07
Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [
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br Acknowledgements br Introduction Benzodiazepine BZ treatm
2022-05-07
Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd
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