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br STAR Methods br Acknowledgments We thank Prof Y Tomari
2022-06-13
STAR★Methods Acknowledgments We thank Prof. Y. Tomari at the University of Tokyo for experimental advice and K. Hanada for technical assistance. This research was supported by Grants-in-Aid for Scientific Research on Innovative Areas “Nascent Chain Biology” (JP15H01548 and JP17H05677 to T.I. a
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br FXR Agonists Azepinol b indole hEC
2022-06-13
FXR Agonists Azepinol[4,5-b]indole 1 (hEC50=600nM, efficacy (eff)=100%) was identified as a FXR agonist lead from a high-throughput screening effort. Structure–activity relationship (SAR) studies around the azepine ring demonstrated that dialkyl substitution at C-1 led to a 30-fold improvement in
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In the present study recipient oestradiol serum levels
2022-06-13
In the present study, recipient oestradiol serum levels on the day of donor oocyte retrieval or warming were found to be significantly higher in the antagonist group and higher than 100 pg/ml in all cases. Serum oestradiol level has been reported to have no effect on endometrial receptiveness in ooc
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dna ligase Research of Kojima et al DeJarnette
2022-06-13
Research of Kojima et al. (2000); DeJarnette et al. (2001), and Saldarriaga et al. (2007) inferred that synchronization of NFWE is related to ovulation response after GnRH-1. In the research of Saldarriaga et al. (2007) with Bos indicus-influenced beef cows, ovulation rate was 40% and estrous synchr
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ICH induced striatal lesion produced a reduction of EAAT exp
2022-06-13
ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino dofetilide transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brain ischemia
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pHi regulation in astrocytes has been examined primarily in
2022-06-13
pHi regulation in astrocytes has been examined primarily in cell culture rather than in situ. Two HCO3−-dependent transporters, NBC and Na+-driven Cl-HCO3 exchange (NDCBE), have been described [10,16], in addition to Cl-HCO3 anion exchange (AE) [96]. Culture studies indicate that NHE is the principa
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To confirm the in vitro findings atorvastatin
2022-06-13
To confirm the in vitro findings, atorvastatin or pravastatin was given to C57BL6/J mice fed with high fat diet. Doses of atorvastatin were set to be 6 mg/kg and 12 mg/kg, which were within clinical therapeutic doses. The results revealed that treatment of atorvastatin but not pravastatin impaired g
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br Acknowledgments br Introduction When human
2022-06-13
Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact Moxifloxacin receptor suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-depend
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Acknowledgements br Introduction Alzheimer s disease AD is
2022-06-10
Acknowledgements Introduction Alzheimer's disease (AD) is a devastating neurodegenerative disorder and the leading cause of dementia. There is currently no treatment available to slow or halt disease progression. The underlying mechanisms of AD on the cell and molecular levels are still not comp
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ulixertinib Two types of processes intrinsic and extrinsic c
2022-06-10
Two types of processes, intrinsic and extrinsic, contribute synergistically to the age-related change on structural integrity and physiological function of the skin (Farage, Miller, Elsner, & Maibach, 2008). Intrinsic aging arise from genetically programmed cell aging, normal metabolic activities, a
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In addition to the robust intracellular calcium
2022-06-10
In addition to the robust intracellular calcium mobilisation, DHA and TUG-891 also induced MMP-9 granules release and superoxide production, supporting a key role of calcium in bovine neutrophil defense responses (Burgos et al., 2011). Pisani et al. (Pisani et al., 2009) described a reduction of bas
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The improved glucose tolerance of Ffar R
2022-06-10
The improved glucose tolerance of Ffar1R258W/R258W mice on HFD was unexpected. In combination with similar fasting blood glucose levels, the significant lower fasting plasma insulin of mutant mice compared to wild-type mice is indicative of improved insulin sensitivity. However, peripheral insulin r
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br Conflict of interest br Acknowledgments The research was
2022-06-10
Conflict of interest Acknowledgments The research was funded by the Major Programs of Pharmaceutical research project of Jiangsu Province (Q2018044). Introduction Lipids are important regulators of cell death. In mammalian cells, both apoptotic and non-apoptotic cell death pathways can be
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A breakthrough in the understanding of
2022-06-10
A breakthrough in the understanding of the unique properties of GPX4-downregulation-induced cell death was accomplished when Seiler et al. in 2008 demonstrated the role of 12/15-lipoxygenase (12/15-LOX), a polyunsaturated fatty Participants metabolizing enzyme [92], in the execution of GPX4-knockou
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Liver and muscle isozymes have been
2022-06-10
Liver and muscle isozymes have been found in vertebrate tissues [2], [5], [6]. The liver FBPase is recognized as a regulatory enzyme of gluconeogenesis. The muscle isozyme participates in the glycogen synthesis from lactate and in the regulation of glycolysis [7], [8], [9]. The basic difference betw
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