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One previously unreported discovery is that Ptgds is alterna
2022-06-20
One previously unreported discovery is that Ptgds is alternatively spliced, such that partial removal of exon 3 correlates with higher levels of regeneration. The absence of exon 3 likely affects the functionality of the final product. The structure of Ptgds is that of the typical lipocalin β-barrel
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With the administration of OM fatty acids
2022-06-20
With the administration of OM3 fatty acids, it has previously been shown that the activation of GPR120 is linked to the secretion and circulating levels of the adipokine adiponectin [123] promoting anti-inflammation (downregulation of NF-κB) and insulin sensitivity [124]. Interestingly, Nrf2 also de
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br Results br Discussion Cell contact mediated spread
2022-06-20
Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenes
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Sickle erythrocytes are known to have an increased adhesion
2022-06-18
Sickle erythrocytes are known to have an increased adhesion to endothelial A 967079 (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the interac
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Studies have shown that coexpression of the HAC gene in
2022-06-18
Studies have shown that coexpression of the HAC1 gene in P. pastoris improved the Isoprenaline HCl level of foreign proteins [24,25]. By coexpression with PDI and Ero1, the expression level of the coexpressed strains was increased by 60% [26]. In our study, the α-galactosidase gene was coexpressed
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D appears to be important
2022-06-18
D83 appears to be important for receptor function as a mutation to an alanine produced a non-functional channel. Interestingly, maintaining the charge as in D83E produced only a small reduction in GABA sensitivity. Other mutations at this position which included residues capable of hydrogen bonding
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The results of our analysis
2022-06-18
The results of our analysis of Fas alleles, Fas 670 A>G, FasL alleles, and FasL IVS2nt 124 A>G for cases and controls are shown in Table 2. For Fas 670, we found statistically significant differences between the two groups regarding the AA Aprotinin sale (P=0.040) and GG/AG (P=0.040) as well as the
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Several other assay parameters were also explored First the
2022-06-18
Several other assay parameters were also explored. First, the thermal dependence of the assay was investigated by measuring the specific activity at different temperatures (Fig. 7). That data show that enzymatic activity increases with increasing temperature. Interestingly, the observed rate increas
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Our observation that glioblastoma tumor
2022-06-18
Our observation that glioblastoma tumor cells express ETA-R in 6/10 cases contrasts with a recent publication reporting ETB-R expression in these tumors [17]. The reason for the discrepancy between that report and the present study might be due to the fact that glioblastomas with oligodendroglial co
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Our extensive preliminary data suggest that the loss of
2022-06-18
Our extensive preliminary data suggest that the loss of p300 (and resulting H3K27ac) is related to inorganic arsenic related diseases. Therefore, it may open a new avenue for alleviating the consequence of H3K27ac, for example, via boosting CBP enzymatic activity for at least partially compensating
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br Hh Proteins at a Glance Hh
2022-06-18
Hh Proteins at a Glance Hh family proteins are evolutionarily conserved morphogens that provide cells with positional information and fate instruction during early embryonic development. After development, Hh ligands contribute to tissue homeostasis and wound healing 1., 2.. Consistent with these
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br Conclusions br Acknowledgments This work was financially
2022-06-18
Conclusions Acknowledgments This work was financially supported partly by Shanghai Pujiang Talent Project (No.: 08PJ14017), the National Natural Science Foundation of China (Nos.: 20771029 and 91013001) and Shanghai Leading Academic Discipline Project (No. B108). Soluble guanylate cyclase (
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This variant has also been related to a better
2022-06-18
This variant has also been related to a better treatment response in patients with metastatic colorectal cancer subjected to irinotecan-based chemotherapy (Kweekel et al., 2008). Inheritance of this metabolic variability has also been stated to influence better treatment outcomes in breast cancer pa
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br GSNOR regulates SA synthesis and SA
2022-06-18
GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic SM-164 (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resistance, le
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GPR GPR GPR GPR and GPR all
2022-06-18
GPR80, GPR81, GPR82, GPR93 and ψGPR79 all shared identities to P2Y GPCRs or P2Y-like oGPCRs. Previously, at least three different nucleotide receptor phenotypes have been observed in mammalian tissue, including GPCRs activated by GDC-0623 nucleotides (e.g. P2Y1 and P2Y11), uridine nucleotides (e.g.
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