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M 1145 We tested formyl MYVKWPWYVWL which we had previously
2022-09-21
We tested formyl-MYVKWPWYVWL, which we had previously shown to have essentially identical Kis for W190/N192, R190/K192 and R190/N190 [8] of 130 nM, for its ability to downregulate surface receptor (Fig. 5A). R190/K192 exhibited the lowest EC50 of 44±4 nM about 3 fold below the observed Ki and a maxi
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GDC0199 receptor Whether ferroptosis specific inhibitor coul
2022-09-21
Whether ferroptosis specific inhibitor could promotes spinal cord repair is a question worth to explore. A potent and stable ferroptosis specific inhibitor is essential for in vivo study. Ferrostatin-1 (Fer-1), the first generation of ferroptosis inhibitor, was shown actively suppressing ferroptosis
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br Acknowledgments This work was supported by the National N
2022-09-20
Acknowledgments This work was supported by the National Natural Science Foundation of China (31100111), the Nature Science Research Project of Anhui Province (1508085MC43), the subject construction project from Anhui Academy of Agricultural Sciences (14A1110). We would like to acknowledge the tec
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Electrochemical techniques have attracted broad attention
2022-09-20
Electrochemical techniques have attracted broad attention for their outstanding advantages, such as satisfactory sensitivity and convenient operation. Nowadays, nucleic rock pathway nanostructures such as DNA tetrahedron structure, nucleic acid-mimicking structure, exhibit noticeable application in
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br Main Text Metabolism drives diverse biological
2022-09-20
Main Text Metabolism drives diverse biological processes including differentiation, proliferation, and effector function in diverse cell types. In particular, the process of mounting an innate immune response to pathogens entails rapid sensing of a wide range of patterns displayed by invading mic
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The rationale for developing HDACi as anticancer agents was
2022-09-20
The rationale for developing HDACi as anticancer agents was based on their ability to induce the hyperacetylation of histones and nonhistone proteins, resulting in increased differentiation, apoptosis, and topotecan arrest of cancer cells 1, 2, 3. HDACi have been used in the treatment of hematologi
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Introduction Cancer has been a significant public health pro
2022-09-20
Introduction Cancer has been a significant public health problem in the world with more patients being diagnosed every year. However, chemotherapy from non-specific cytotoxic agents that as an effective means of cancer treatment is limited by severe side effects and poor selectivity. Thus, the deve
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Author contribution br Funding This work was
2022-09-20
Author contribution Funding This work was supported by funding from St Vincent’s AMR. Hologic provided Panther equipment and Aptima HCV Quant Dx Viral Load assays. The sponsors had no rule in the analysis and interpretation of the study results, the manufacturer of reagents used in this study d
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Unlike the bacterial SRP pathway for which
2022-09-20
Unlike the bacterial SRP pathway for which the energetics, kinetics, and structure of almost every intermediate have been characterized, multiple questions remain for the GET pathway (Figure 3, marked with ‘?’). First, the targeting pathway demands distinct activities of Get3 before and after substr
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Here we used Drosophila and mouse models to address the
2022-09-20
Here, we used Drosophila and mouse models to address the biological function of RALs in the adult intestine. Our results demonstrate a conserved in vivo role for RALs in ISC function during tissue homeostasis and regeneration. ISCs lacking RALs were at a disadvantage compared to wild-type neighbors.
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br Rho family GTPases are molecular switches most which cycl
2022-09-20
Rho-family GTPases are molecular switches; most which cycle from an ‘on’ GTP bound state to an ‘off’ GDP bound state, driven by GEFs (guanine nucleotide exchange factors) and GAPs (GTPase-activating proteins) respectively. Association with lipid membranes through a lipid (farnesyl or geranylgerany
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Glycogen synthase kinase GSK is an evolutionarily conserved
2022-09-20
Glycogen synthase kinase-3β (GSK-3β) is an evolutionarily conserved serine/threonine kinase that plays multifaceted role in diverse cellular and neurophysiological processes [8]. GSK-3β is regulated by inhibitory serine and stimulatory tyrosine phosphorylation on Ser9 and Tyr216 respectively [9]. Dy
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The beta catenin TCF complex
2022-09-20
The beta-catenin/TCF complex is an important target in the Wnt/beta-catenin pathway. This complex has proven challenging to target. However, natural inhibitors of this complex have been identified. One group of inhibitors is called the inhibitors of Wnt response (IWR-1/2). IWR-1/2 targets Axin and
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br Declaration of interest br Acknowledgments br This work
2022-09-20
Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A
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GPR A a G protein coupled
2022-09-20
GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic Imiquimod hydrochloride [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation of GPR109A leads
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